| Main Title |
Interspecies Comparisons of Benzo(a)pyrene Metabolism and DNA-Adduct Formation in Cultured Human and Animal Bladder and Tracheobronchial Tissues. |
| Author |
Daniel, F. B. ;
Schut, H. A. J. ;
Sandwisch, D. W. ;
Schenck, K. M. ;
Hoffmann, C. O. ;
|
| CORP Author |
Health Effects Research Lab., Cincinnati, OH. ;Medical Coll. of Ohio at Toledo. |
| Year Published |
1983 |
| Report Number |
EPA/600/J/-83/240; |
| Stock Number |
PB84-245570 |
| Additional Subjects |
Deoxyribonucleic acids ;
Comparisons ;
Metabolism ;
Tissues(Biology) ;
Reprints ;
Benzopyrene ;
Carcinogens
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-245570 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
Cultured bladder and tracheobronchial explants from human, monkey, dog, hamster, and rat were used to study the metabolism, covalent binding to DNA, and DNA:adduct formation of (3H0benzo(a)pyrene (BP). Both organs from all species formed large amounts (40 to 70% of total 3H in the medium after 24 hr of incubation) of polar material and small amounts (<1% for animal tissues and 1 to 5% for human tissues) of organic solvent-extractable (unconjugated) metabolites, with the balance (14 to 38%) being unmetabolized BP. |
| Supplementary Notes |
Prepared in cooperation with Medical Coll. of Ohio at Toledo. |
| Availability Notes |
Pub. in Cancer Research 43, p4723-4729 Oct 83. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Interspecies Comparisons of Benzo(a)pyrene Metabolism and DNA-Adduct Formation in Cultured Human and Animal Bladder and Tracheobronchial Tissues. |
| PUB Date Free Form |
c1983 |
| Category Codes |
6T; 6A; 57Y; 57B |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
435627047 |
| Origin |
NTIS |
| Type |
CAT |
