Main Title |
7,12-Dimethylbenz(a)anthracene-Deoxyribonucleoside Adduct Formation 'in vivo': Evidence for the Formation and Binding of a Monohydroxymethyl-DMBA (Dimethylbenz(a)anthracene) Metabolite to Rat Liver DNA (Deoxyribonucleic Acid). |
Author |
Joyce, N. J. ;
Daniel, F. B. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1982 |
Report Number |
EPA-600/J-82-275; |
Stock Number |
PB83-163477 |
Additional Subjects |
Carcinogens ;
Deoxyribonucleic acids ;
Rats ;
Liver ;
Deoxyribonucleic acids ;
Parenteral infusions ;
Chemical analysis ;
Fluorescence ;
Aromatic polycyclic hydrocarbons ;
Malignant neoplasms ;
Reprints ;
Benzanthracene/dimethyl ;
Benzanthracene/hydroxymethyl-dimethyl ;
High performance liquid chromatography ;
Cancer
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB83-163477 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
The polycyclic aromatic hydrocarbon, 7,12-dimethyl benz(a)anthracene (DMBA) is a potent carcinogen to the female Sprague-Dawley rat, and when administered under conditions that have been shown to produce cancer, results in extensive formation of hydrocarbon-deoxyribonucleoside adducts. Sephadex LH-20 and reverse-phase h.p.l.c. and spectrofluorometric analysis of these adducts demonstrate that at least one adduct results from the binding of 7,12-dimethylbenz(a)anthracene-1,2,3,4-tetrahydro-3,4-dihydroxy-1,2-oxide. |
Supplementary Notes |
Pub. in Carcinogenesis, v3 n3 p297-301 1982. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: 7,12-Dimethylbenz(a)anthracene-Deoxyribonucleoside Adduct Formation 'in vivo': Evidence for the Formation and Binding of a Monohydroxymethyl-DMBA (Dimethylbenz(a)anthracene) Metabolite to Rat Liver DNA (Deoxyribonucleic Acid). |
PUB Date Free Form |
1982 |
Category Codes |
6T; 7D; 57Y; 99A |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
314724386 |
Origin |
NTIS |
Type |
CAT |