Main Title |
DNA Adducts in Rat Lung, Liver and Peripheral Blood Lymphocytes Produces by i.p. Administration of Benzo(a)Pyrene Metabolites and Derivatives. |
Author |
Ross, J. ;
Nelson, G. ;
Erexson, G. ;
Kligerman, A. ;
Earley, K. ;
|
CORP Author |
Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Kentucky Univ., Lexington.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1991 |
Year Published |
1991 |
Report Number |
EPA-68-02-4456; EPA/600/J-91/306; |
Stock Number |
PB92-124627 |
Additional Subjects |
Deoxyribonucleic acids ;
Lung ;
Liver ;
Lymphocytes ;
Benzo(a)pyrene ;
DNA damage ;
Rats ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB92-124627 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
5p |
Abstract |
DNA adducts produced in vivo in rat lung, liver, and peripheral blood lymphocytes following the i.p. administration of several synthetic benzo(a)pyrene (B(a)P) metabolites and ring-substituted derivatives have been analyzed by the nuclease P1 version of the 32P-postlabeling assay. These include 1-,2-,3-,4-,5-,6-,7-,8-,9-,10-,11-, and 12-hydroxyB(a)P, (+ or -) -B(a)P-trans-4,5-dihydrodiol, (+ or -) -B(a)P-trans-7,8-dihydrodiol, (+ or -) -B(a)P-trans-9,10-dihydrodoil, and B(a)P-7,8-dione. Among the monohydroxy derivatives, only 2-,9-, and 12-hydroxyB(a)P produced detectable adducts. The only disubstituted derivative studied which produced adducts was the trans-7,8-dihydrodiol. The resulting DNA adducts were compared to those produced in each tissue by administration of B(a)P. 9-hydroxyB(a)P and B(a)P-trans-7,8-dihydrodiol each lead to the formation of major B(a)P adducts seen in lung and liver, respectively. None of the adducts derived from either 2-hydroxyB(a)P or 12-hydroxyB(a)P were observed following administration of B(a)P alone. |
Supplementary Notes |
Pub. in Carcinogenesis, v12 n10 p1953-1955 Oct 91. Prepared in cooperation with Kentucky Univ., Lexington. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: DNA Adducts in Rat Lung, Liver and Peripheral Blood Lymphocytes Produces by i.p. Administration of Benzo(a)Pyrene Metabolites and Derivatives. |
Category Codes |
57Y; 57F |
NTIS Prices |
PC A01/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
203826627 |
Origin |
NTIS |
Type |
CAT |