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RECORD NUMBER: 51 OF 448Main Title | Biochemical Effects of Three Chlorinated Phenols in Rat Liver. | |||||||||||
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Author | Kitchin, K. T. ; Brown., J. L. ; | |||||||||||
CORP Author | Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
Publisher | c1988 | |||||||||||
Year Published | 1988 | |||||||||||
Report Number | EPA/600/J-88/522; | |||||||||||
Stock Number | PB90-232265 | |||||||||||
Additional Subjects | Biochemistry ; Toxicology ; Liver ; Phenols ; Chlorinated hydrocarbons ; Leukocytes ; Rats ; Carcinogens ; Lethal dosage ; Tables(Data) ; Reprints ; Dose-response relationships ; DNA damage ; Cytochrome P-450 ; Ornithine decarboxylase ; Glutathione ; Alanine aminotransferase ; Enzyme induction | |||||||||||
Holdings |
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Collation | 10p | |||||||||||
Abstract | The hepatic biochemical effects of four chlorinated oxygen containing environmental contaminants were determined. Two oral doses of 1/5 the LD50 of 2,4-dichlorophenoxyacetic acid, 2,4,5-trichlorophenol, 2,4,6-trichlorophenol and 2,3,4,6-tetrachlorophenol were given 21 and 4 hours before sacrifice to adult female rats. Although 2,4,6-trichlorophenol is a carcinogen in lifetime rodent studies, no evidence was found for DNA damage in rat liver or the white cells of rat blood. Similiarly no compound related changes were found in serum alanine aminotransferase, hepatic glutathione or cytochrome P-450 content. A dose of 193 mg/kg/day (slightly over the published rat LD50) of 2,3,4,6-tetrachlorophenol increased 5-fold the activity of hepatic ornithine decarboxylase. As 2,4,6-trichlorophenol did not damage DNA or induce hepatic ornithine decarboxylase (a marker of carcinogenic promotion) in the study, no explanation is apparent why this molecule is a carcinogen in rodent lifetime exposures and structurally related congeners are not. (Copyright (c) 1988 Gordon and Breach, Science Publishers, Inc.) | |||||||||||
Supplementary Notes | Pub. in Toxicological and Environmental Chemistry, v16 p165-172 Feb 88. | |||||||||||
NTIS Title Notes | Journal article. | |||||||||||
Title Annotations | Reprint: Biochemical Effects of Three Chlorinated Phenols in Rat Liver. | |||||||||||
Category Codes | 57Y; 57B | |||||||||||
NTIS Prices | PC A02/MF A01 | |||||||||||
Primary Description | 600/10 | |||||||||||
Document Type | NT | |||||||||||
Cataloging Source | NTIS/MT | |||||||||||
Control Number | 022221230 | |||||||||||
Origin | NTIS | |||||||||||
Type | CAT |