| Main Title |
Norepinephrine and Epidermal Growth Factor: Dynamics of Their Interaction in the Stimulation of Hepatocyte DNA Synthesis. |
| Author |
Cruise, J. L. ;
Mechalopoulos, G. ;
|
| CORP Author |
Duke Univ. Medical Center, Durham, NC. Dept. of Pathology.;Health Effects Research Lab., Research Triangle Park, NC.;National Institutes of Health, Bethesda, MD. |
| Year Published |
1985 |
| Report Number |
EPA-R-811687; EPA/600/J-85/525; |
| Stock Number |
PB88-185582 |
| Additional Subjects |
Norepinephrine ;
Liver ;
Cells(Biology) ;
Deoxyribonucleic acid ;
Synthesis ;
Cultures(Biology) ;
Stimulation ;
Reprints ;
Epidermal growth factor ;
Epithelium
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-185582 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
Primary cultures of adult rat hepatocytes are stimulated to enter DNA synthesis by norepinephrine (NE). This stimulation is maximal if the hepatocytes are incubated with NE for more than 12 hr, beginning no later than 2-4 hr after the cells are first plated. After 24 hr in culture, hepatocytes are unresponsive to NE stimulation. A strong synerergistic interaction between NE and epidermal growth factor (EGF) may be observed in cultures incubated with both EGF and NE, or pretreated with NE, then exposed to EGF. This interaction may be related to the finding that NE, in similarity with other factors that enhance EGF stimulation, reduces binding at the EGF receptor during the first 24 hr in culture. (Copyright (c) Alan R. Liss, Inc.) |
| Supplementary Notes |
Pub. in Jnl. of Cellular Physiology, v125 p45-50 1985. Sponsored by Health Effects Research Lab., Research Triangle Park, NC., and National Institutes of Health, Bethesda, MD. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Norepinephrine and Epidermal Growth Factor: Dynamics of their Interaction in the Stimulation of Hepatocyte DNA Synthesis. |
| PUB Date Free Form |
c1985 |
| Category Codes |
57F; 57S |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
816223055 |
| Origin |
NTIS |
| Type |
CAT |
