Main Title |
Carcinogenicity of Dichloroacetic Acid in the Male B6C3F1 Mouse. |
Author |
DeAngelo, A. B. ;
Daniel, F. B. ;
Stober, J. A. ;
Olson, G. R. ;
|
CORP Author |
Health Effects Research Lab., Cincinnati, OH. ;Pathology Associates, Inc., West Chester, OH. |
Publisher |
c1991 |
Year Published |
1991 |
Report Number |
EPA/600/J-91/051; |
Stock Number |
PB91-191585 |
Additional Subjects |
Dichloroacetate ;
Potable water ;
Water pollution effects(Animals) ;
Carcinogens ;
Mice ;
Liver neoplasms ;
Carcinogenicity tests ;
Hyperplasia ;
Adenoma ;
Organ weight ;
Body weight ;
Pathology ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-191585 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
13p |
Abstract |
Groups of male B6C3F mice (N=50) were provided drinking water containing 2 g/liter sodium chloride (control) and 0.05, 0.5 and 5 g/liter dichloroacetic acid (DCA). Treatment of 30 animals in each group was carried out to 60 or 75 weeks. In a separate experiment, mice exposed to 3.5 g/liter DCA and the corresponding acetic acid control group were killed at 60 weeks. Groups of 5 mice were killed at 4, 15, 30 and 45 weeks. Time=weighted mean daily doses of 7.6, 77, 410, and 486 mg/kg/day were calculated for 0.05, 0.5, 3.5, and 5 g/liter DCA treatments. Animals exposed to 3.5 and 5 g/liter DCA had final body weights that were 87 and 83%, respectively of the control value. Relative liver weights of 136, 230, and 351% of the control value were measured for 0.5, 3.5 and 5 g/liter, respectively. At 60 weeks mice receiving 5.0 g/liter DCA had a 90% prevalence of liver neoplasia with a mean multiplicity of 4.50 tumors/animal. Exposure to 3.5 g/liter DCA for 60 weeks resulted in a 100% tumor prevalence with an average of 4.0 tumors/animal. No liver tumors were found in the group treated with acetic acid. Hyperplastic nodules were seen in the 3.5 (58%; 0.92/animal) and 5 g/liter DCA groups (83%; 1.27/animal). |
Supplementary Notes |
Pub. in Fundamental and Applied Toxicology, v16 n2 p337-347 Feb 91. Prepared in cooperation with Pathology Associates, Inc., West Chester, OH. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Carcinogenicity of Dichloroacetic Acid in the Male B6C3F1 Mouse. |
Category Codes |
57Y; 57U; 68D |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
119326327 |
Origin |
NTIS |
Type |
CAT |