Main Title |
Pulmonary Function in Elastase-Treated Guinea Pigs and Rats Exposed to Ammonium Sulfate or Ammonium Nitrate Aerosols. |
Author |
Loscutoff, S. M. ;
Cannon, W. C. ;
Buschbom, R. L. ;
Busch, R. H. ;
Killand, B. W. ;
|
CORP Author |
Battelle Pacific Northwest Labs., Richland, WA.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1985 |
Report Number |
EPA/600/J-85/031; |
Stock Number |
PB85-220333 |
Additional Subjects |
Ammonium nitrate ;
Ammonium sulfate ;
Aerosols ;
Toxicology ;
Aerosols ;
Laboratory animals ;
Rats ;
Pigs ;
Reprints ;
Air pollution effects(Animals) ;
Lung function tests
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-220333 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
13p |
Abstract |
Three weeks following intratracheal instillations of elastase dissolved in saline, or saline alone, guinea pigs and rats were exposed for 5 or 20 days, 6 hr/day, 5 days/week to filtered room air, 1 mg/cu.m. ammonium sulfate ((NH4)2SO4) or 1 mg/cu.m. ammonium nitrate (NH4NO3) aerosols. Pulmonary function evaluations conducted in guinea pigs showed no detrimental effects of (NH4)2SO4) or NH4NO3 exposure and very little effect of elastase treatment. Lung function changes in elastase treated rats were consistent with a condition of experimentally induced pulmonary emphysema. Rats exposed to NH4NO3 aerosols showed no consistent exposure-related changes. Compared with air-exposed animals, rats exposed to (NH4)2SO4 aerosols had increased values of residual volume and functional residual capacity and decreased slope of single-breath N2 washout curves. The authors conclude that elastase treatment had no significant effect on lung function changes resulting from inhalation of (NH4)2SO4 aerosols. Lung function was more affected by (NH4)2SO4 exposure than by NH4NO3 exposure, and lung function changes were more pronounced in rats than in guinea pigs. |
Availability Notes |
Pub. in Environmental Research 36, n1 p170-180 Feb 85. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Pulmonary Function in Elastase-Treated Guinea Pigs and Rats Exposed to Ammonium Sulfate or Ammonium Nitrate Aerosols. |
PUB Date Free Form |
c1985 |
Category Codes |
6T; 57Y; 68A |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
525518733 |
Origin |
NTIS |
Type |
CAT |