Main Title |
Formation of Mutagens Following Chlorination of Humic Acid: A Model for Mutagen Formation during Drinking Water Treatment. |
Author |
Meier, J. R. ;
Lingg, R. D. ;
Bull, R. J. ;
|
CORP Author |
Health Effects Research Lab., Cincinnati, OH. |
Year Published |
1983 |
Report Number |
EPA-600/J-83-151; |
Stock Number |
PB84-153709 |
Additional Subjects |
Water treatment ;
Chlorination ;
Mutagens ;
Humic acids ;
Potable water ;
Laboratory animals ;
Mathematical models ;
Sampling ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB84-153709 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
18p |
Abstract |
Aqueous chlorination of humic acids results in the formation of compounds with direct-acting mutagenic activity in the Ames/Salmonella plate assay for tester strains TA98, TA100, TA1535, TA1537, and TA1538. The addition of a rat liver microsomal fraction (S-9) plus cofactors causes a substantial decrease of activity, the extent of which is tester strain dependent. The mutagenic activity is due predominantly to non-volatile compounds. Production of mutagens is greatly dependent on the chlorination pH, with a pattern of decreasing mutagenic activity with increasing pH. This order of activity could be at least partially explained by the alkali-liability of the compounds. Chlorination of commercial humic acids is proposed as a model for examination of mutagen formation during water chlorination. |
Supplementary Notes |
Pub. in Mutation Research 118, p25-41 1983. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Formation of Mutagens Following Chlorination of Humic Acid: A Model for Mutagen Formation during Drinking Water Treatment. |
PUB Date Free Form |
17 Feb 83 |
Category Codes |
6T; 13B; 68D; 57Y; 50B |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
411842243 |
Origin |
NTIS |
Type |
CAT |