Main Title |
Disruption of Human Eyeblink Conditioning After Central Cholinergic Blockade with Scopolamine. |
Author |
Solomon, P. R. ;
Groccia-Ellison, M. ;
Flynn, D. ;
Mirak, J. ;
Edwards, K. R. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1993 |
Year Published |
1993 |
Report Number |
EPA/600/J-93/362; |
Stock Number |
PB93-228880 |
Additional Subjects |
Scopolamine ;
Cholinergic receptors ;
Eyelid conditioning ;
Pharmacology ;
Humans ;
Auditory threshold ;
Cognition ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-228880 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
11p |
Abstract |
Human volunteers (N = 72) received saline, a low dose of oral scopolamine (0.6 mg), a high dose of oral scopolamine (1.2 mg), or a peripheral analogue (glycopyrrolate). They then underwent classical conditioning of the eyeblink response to a tone conditioned stimulus (CS) and a corneal airpuff unconditioned stimulus (UCS) in a delay conditioning paradigm. There was a dose-related decline in acquisition of the conditioned response. These drug-induced conditioning deficits were similar to those previously reported in rabbit eyeblink conditioning and could not be attributed to such nonassociative factors as changes in auditory thresholds to the tone CS, magnitude of reflexive blinks to the airpuff UCS, or to changes in spontaneous blink rates. (Copyright (c) 1993 by the American Psychological Association, Inc.) |
Supplementary Notes |
Pub. in Behavioral Neuroscience, v107 n2 p271-279 Apr 93. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Disruption of Human Eyeblink Conditioning After Central Cholinergic Blockade with Scopolamine. |
Category Codes |
57Q; 57S |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
329432387 |
Origin |
NTIS |
Type |
CAT |