||Prenatal Exposure to Methylmercury Alters Development of Adrenergic Receptor Binding Sites in Peripheral Sympathetic Target Tissues.
Slotkin, T. A. ;
Orband, L. ;
Cowdery, T. ;
Kavlock, R. J. ;
Bartolome, J. ;
||Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Mercury organic compounds ;
Methylmercury compounds ;
Prenatal exposure delayed effects ;
Dose-response relationship ;
Binding sites ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||In order to assess the impact of prenatal exposure to methylmercury on sympathetic neurotransmission, effects on development of adrenergic receptor binding sites in peripheral tissues was evaluated. In the liver, methylmercury produced a dose-dependent increase in alpha sub 1, alpha sub 2 and beta-receptor binding of radioliganda throughout the first 5 weeks of postnatal life. Similarly, renal alpha-receptor subtypes showed increased binding capabilities, but binding to alpha-receptor sites was reduced. At least some of the changes in receptors appear to be of functional significance, as physiological reactivity to adrenergic stimulation is altered in the same directions in these two tissues. The actions of methylmercury displayed tissue specificity in that the same receptor populations were largely unaffected in other tissues (lung, heart). These results suggest that methylmercury exposure in utero alters adrenergic responses through targeted effects on postsynaptic receptor populations in specific tissues. (Copyright (c) Elsevier Science Publishers B.V. (Biomedical Division).)
||Pub. in Toxicology Letters, v35 p285-295 1987. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Prenatal Exposure to Methylmercury Alters Development of Adrenergic Receptor Binding Sites in Peripheral Sympathetic Target Tissues.
|PUB Date Free Form
||PC A03/MF A01