Main Title |
Piperonyl Butoxide as a Tool in Aquatic Toxicological Research with Organophosphate Insecticides. |
Author |
Ankley, G. T. ;
Dierkes, J. R. ;
Jensen, D. A. ;
Peterson., G. S. ;
|
CORP Author |
Environmental Research Lab., Duluth, MN. ;AScI Corp., Duluth, MN. |
Publisher |
c1991 |
Year Published |
1991 |
Report Number |
EPA/600/J-91/173; |
Stock Number |
PB91-231415 |
Additional Subjects |
Toxicology ;
Organophosphate insecticides ;
Piperonyl butoxide ;
Water pollution effects(Animals) ;
Daphnia ;
Cytochrome p-450 ;
Metabolic activation ;
Diazinon ;
Malathion ;
Methyl parathion ;
Parathion ;
Reprints ;
Ceriodaphnia dubia
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-231415 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
Experiments were conducted to determine the effects of piperonyl butoxide, a synthetic methylenedioxphenyl inhibitor of cytochrome(s) P450, on the toxicity of organophosphate insecticides to three cladoceran test species: Ceriodaphnia dubia, Daphnia magna, and Daphnia pulex. Coadministration of piperonyl butoxide effectively reduced the acute toxicity of four metabolically activated organophosphates (parathion, methyl parathion, diazinon, and malathion) and did not affect the toxicity of three organophosphates not requiring metabolic activation (dichlorvos, chlorfenvinphos, and mevinphos). These results indicate that piperonyl butoxide may be an effective tool in toxicological research focused upon identifying specific compounds responsible for toxicity in complex aqueous mixtures. (Copyright (c) 1991 Academic Press, Inc.) |
Supplementary Notes |
Pub. in Ecotoxicology and Environmental Safety, v21 p266-274 Jun 91. Prepared in cooperation with AScI Corp., Duluth, MN. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Piperonyl Butoxide as a Tool in Aquatic Toxicological Research with Organophosphate Insecticides. |
Category Codes |
68E; 57Y; 57H |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/03 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
128229665 |
Origin |
NTIS |
Type |
CAT |