Main Title |
Renal Functional Teratogenesis Resulting from Adriamycin Exposure (Journal Version). |
Author |
Kavlock, R. J. ;
Rogers, E. H. ;
Rehnberg, B. F. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
1986 |
Year Published |
1986 |
Report Number |
EPA/600/J-86/482; |
Stock Number |
PB89-105423 |
Additional Subjects |
Toxicity ;
Adriamycin ;
Teratogens ;
Kidney ;
Prenatal exposure delayed effects ;
Kidney function tests ;
Laboratory animals ;
Pregnancy ;
Exposure ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-105423 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
11p |
Abstract |
Pregnant Sprague Dawley rats were exposed to adriamycin, an anthracycline antibiotic used in the treatment of neoplasms, and offspring were evaluated for renal functional competence using a variety of physiological techniques. Exposure consisted of 0, 1.0 or 1.5 mg/kg by intraperitoneal injection on either gestational days 7-10 or 10-12. Exposure during days 7-10 of gestation produced greater evidence of overt developmental toxicity than did exposure during days 10-12 of gestation. The reverse was true, however, for the effects of adriamycin on renal function, as the majority of effects on these measures (including decreased creatinine clearance, increased fractional excretion of water, decreased renal concentrating ability and decreased ability to excrete an acid load) were found in the high dose pups exposed during days 10-12 of gestation. |
Supplementary Notes |
Pub. in Teratology, v33 p213-220 1986. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Renal Functional Teratogenesis Resulting from Adriamycin Exposure (Journal Version). |
Category Codes |
57Q; 57Y |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
834421646 |
Origin |
NTIS |
Type |
CAT |