| Main Title |
Chronic Oral Toxicity and Carcinogenicity Study with Formal Dehyde in Rats, Pharmacokinetics and Metabolism of Ingested and Inhaled Formaldehyde with Cover Letter dated 04/19/88. |
| CORP Author |
CanTox, Inc., Ontario, Canada. ;Hoechst Celanese Corp., Summit, NJ.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
5 May 1988 |
| Year Published |
1988 |
| Report Number |
FYI-OTS-0588-0612; |
| Stock Number |
OTS-0000612-0 |
| Additional Subjects |
Metabolism ;
Pharmacokinetics ;
Formaldehyde ;
Diets ;
Ingestion ;
Inhalation ;
Blood ;
Foods ;
Chemical analysis ;
Toxicity ;
Rats ;
Carcinogenicity ;
Analytical methods ;
Environmental exposure pathway ;
Hoechst Celanese(Trademark)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000612-0 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
352p |
| Abstract |
Formaldehyde is a normal metabolite found at low levels in the blood of healthy individuals. It is an essential compound in intermediary metabolism and provides one-carbon units used in the synthesis of many important biomolecules. The purpose of this report is to examine the metabolism and pharmacokinetics of formaldehyde in an attempt to assess whether the intake of formaldehyde from food and environmental sources is likely to result in its accumulation in the body. The steps taken to determine the levels of formaldehyde in food and to subsequently estimate the per capita daily intake of formaldehyde are described. The available literature which describes the metabolism of formaldehyde in animals and man is summarized and pharmacokinetic data are used to assess the effects of ingested and inhaled formaldehyde on the formaldehyde blood and body pools. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| Category Codes |
57Y; 57B; 57D; 57Q |
| NTIS Prices |
PC A17/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019102920 |
| Origin |
NTIS |
| Type |
CAT |
