| Main Title |
Interactions of various pollutants on causation of pulmonary disease / |
| Author |
Ehrlich, Richard,
|
| Other Authors |
|
| CORP Author |
IIT Research Inst., Chicago, IL.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory, |
| Year Published |
1978 |
| Report Number |
EPA-600/1-78-057; EPA-68-02-2274 |
| Stock Number |
PB-288 363 |
| OCLC Number |
52473331 |
| Subjects |
Air--Pollution--Health aspects ;
Pollutants--Health aspects
|
| Additional Subjects |
Respiratory diseases ;
Toxicology ;
Streptococcus ;
Air pollution ;
Interactions ;
Exposure ;
Infectious diseases ;
Resistance ;
Public health ;
Mice ;
Bacteria ;
Pneumonia ;
Enzymes ;
Concentration(Composition) ;
Nitrogen dioxide ;
Ozone ;
Tolerances(Physiology) ;
Sulfur dioxide ;
Ammonium sulfate ;
Zinc sulfates ;
Recommendations ;
Experimental data ;
Laboratory animals ;
Toxic substances ;
Infections ;
Air pollution effects(Humans) ;
Synergism ;
Animal models ;
Streptococcus pyogenes ;
Environmental health
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 600-1-78-057 |
c.1 |
Headquarters Library/Washington,DC |
06/09/2014 |
| EKBD |
EPA-600/1-78-057 |
|
Research Triangle Park Library/RTP, NC |
06/20/2003 |
| ELBD ARCHIVE |
EPA 600-1-78-057 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| ELBD RPS |
EPA 600-1-78-057 |
repository copy |
AWBERC Library/Cincinnati,OH |
04/16/2018 |
| NTIS |
PB-288 363 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
x, 49 pages : illustrations ; 28 cm |
| Abstract |
Studies were conducted to determine the effects of single and multiple exposures to individual and pollutant mixtures on resistance to respiratory infections. Results of NO2 studies indicate the greater importance of short-term peak concentrations than prolonged exposures to lower concentrations in increasing the susceptibility to infections. Single 3-hr exposure to mixtures containing various concentrations of NO2 and O3 had an additive effect. Repeated 3-hr exposures for 4 weeks to mixtures consisting of 3760 micrograms/cu m NO2 and 98 micrograms/cu m O3 suggested a synergistic interaction between the two pollutants. Daily 3-hr exposures for 6 months to mixtures of 940 micrograms/cu m NO2 and 196 micrograms/cu m O3 resulted in significant excess mortality, and reduced mean survival time in infected animals. Continuation of exposure to the pollutants for 14 days after the infectious challenge resulted in a pronounced increased susceptibility to the respiratory infection, after 1, 2 or 3 month exposure. In non-infected mice this exposure regimen induced changes in the activity of several serum enzymes. |
| Notes |
Project Officer: Donald E. Gardner. IIT Research Institute Contract Number: 68-02-2274 "August 1978." "EPA-600/1-78-057." Includes bibliographical references. |
| Place Published |
Research Triangle Park, N.C. |
| Access Notes |
Also available via the World Wide Web. |
| Corporate Au Added Ent |
United States. Environmental Protection Agency.; United States. Environmental Protection Agency. Office of Research and Development.; Health Effects Research Laboratory (Research Triangle Park, N.C.); IIT Research Institute. |
| PUB Date Free Form |
1978 |
| NTIS Prices |
PC A04/MF A01 |
| BIB Level |
m |
| Medium |
unmediated |
| Content |
text |
| Carrier |
volume |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20180328112711 |
| Language |
eng |
| Origin |
OCLC |
| Type |
MERGE |
| OCLC Rec Leader |
01954cam 2200469Ka 45010 |
