| Main Title |
Type A Viral Hepatitis: Effect of Chlorine on Infectivity. |
| Author |
Peterson, David A. ;
|
| CORP Author |
Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL.;Municipal Environmental Research Lab., Cincinnati, OH. |
| Year Published |
1982 |
| Report Number |
EPA-R-805986; EPA-600/2-82-089; |
| Stock Number |
PB83-115170 |
| Additional Subjects |
Viruses ;
Chlorination ;
Disinfection ;
Water treatment chemicals ;
Monkeys ;
Laboratory animals ;
Microorganism control(Water) ;
Potable water ;
Toxicity ;
Hepatitis A viruses ;
Infectivity ;
Marmosets ;
Pathogens ;
Drinking water ;
Water pollution control
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-115170 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
30p |
| Abstract |
The objective of this study was to determine the effect of (HOCl) treatment on the infectivity of hepatitis A virus (HAV). Prodromal chimpanzee feces, shown to induce hepatitis in marmosets (Saginus sp.), was clarified (JA 20/8K/30 min/5C), the virus precipitated with 7% PEG 6000, harvested (JA 20/8K/30 min/5C) and resuspended. The suspensions were layered onto 5-30% linear surcrose gradients, centrifuged (SW27/25K/3 hrs/5C) and the fractions containing HAV were pooled, dialyzed and ampulized. A 1:500,000 dilution of this preparation induced hepatitis in 2/4 and seroconversion in 2/4 marmosets. A 1:50 dilution of this preparation that routinely produced hepatitis in 100% of the marmosets inoculated served as inoculum for subsequent experiments. |
| NTIS Title Notes |
Final rept. 1 Aug 78-20 Dec 81. |
| PUB Date Free Form |
Oct 82 |
| Category Codes |
6F; 6M; 6T; 68D; 57K; 57Y |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/14 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
303625209 |
| Origin |
NTIS |
| Type |
CAT |
