| Main Title |
Retinoidal Benzoic Acids (Arotenoids) and Other Retinoids Inhibit In vitro Transformation of Epithelial Cells. |
| Author |
Mass., M. J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
EPA/600/J-90/077; |
| Stock Number |
PB90-245499 |
| Additional Subjects |
Trachea ;
Epithelium ;
In vitro analysis ;
Carcinogens ;
Cells(Biology) ;
Reprints ;
Retinoids ;
Neoplastic cell transformation ;
Methylnitronitrosoguanidine ;
Dose-response relationships ;
Cell survival
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-245499 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
Five retinoids were evaluated for their ability to inhibit N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation of primary rat tracheal epithelial (RTE) cells in culture at concentrations that did not affect cell survival. Two retinoidal benzoic acids (arotenoids), Ro 13-6298 and Ro 13-7410, suppressed the transformation frequency by 80-90% at 330 pM whereas at 330 pM retinoic acid suppressed the transformation frequency by 50%. In addition, retinol and retinyl acetate were tested at 33 nM and found to be much less effective than RA at this concentration. In studies with all retinoids, the spontaneously occurring transformed epithelial foci were suppressed from arising by a greater extent than were those that arose in response to carcinogen treatment. A biological difference between carcinogen-induced and spontaneously arising foci is suggested by this result. |
| Supplementary Notes |
Pub. in Jnl. of Anticancer Research, v10 p241-246 Jan 90. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Retinoidal Benzoic Acids (Arotenoids) and Other Retinoids Inhibit In vitro Transformation of Epithelial Cells. |
| Category Codes |
57Q; 57Y; 57F |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
024228051 |
| Origin |
NTIS |
| Type |
CAT |
