| Main Title |
Tris(dichloropropyl)phoshate, a Mutagenic Flame Retardant: Frequent Occurrence in Human Seminal Plasma. |
| Author |
Hudec, Thomas ;
Thean, James ;
Kuehl, Douglas ;
Dougherty, Ralph C. ;
|
| CORP Author |
Florida State Univ., Tallahassee. Dept. of Chemistry.;Environmental Research Lab.-Duluth, MN. |
| Year Published |
1980 |
| Report Number |
EPA-600/J-81-341; |
| Stock Number |
PB82-127879 |
| Additional Subjects |
Chemical analysis ;
Fire resistant textiles ;
Toxicology ;
Mutagens ;
Sampling ;
Extraction ;
Humans ;
Reprints ;
Phosphoric acid/tris(dichloropropyl-ester)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB82-127879 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
Negative-chemical-ionization mass spectral screening of extracts of human seminal plasma has revealed a presence of a Cl7 ion cluster at a mass-to-charge ratio (m/z) of 463 in a significant number of the samples examined (34 out of 123). Experiments with different gases used to generate the negative-chemical-ionization plasma indicated that the ion at m/z 463 was a chloride adduct of a Cl6 molecule with a mass of 428 daltons. Negative-chemical-ionization mass measurement with ions from the iodoform mass spectrum used as reference peaks gave a mass of 427.882 daltons; C9H15O4PCl6 has a molecular weight of 427.883. Extraction of polyurethane foam with toluene produced an extract that consistently gave a negative-chemical-ionization spectrum containing an intense Cl7 ion at m/z 463. The component producing this ion was isolated, and its proton nuclear magnetic resonance spectrum confirmed that it was tris(1,3-dichloro-2-propyl)phosphate, a mutagenic flame retardant. The negative-chemical-ionization screening evidence suggests that this flame retardant or its isomer tris(2,3-dichloro-1-propyl)phosphate, or both, are absorbed into the body from formulations in which they are used as flame retardants. Remedial action indicated reduced human exposure to these compounds. |
| Supplementary Notes |
Pub. in Science, v211 p951-952 , 27 Feb 81. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Tris(dichloropropyl)phoshate, a Mutagenic Flame Retardant: Frequent Occurrence in Human Seminal Plasma. |
| PUB Date Free Form |
18 Nov 80 |
| Category Codes |
7D; 6T; 99F; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323807877 |
| Origin |
NTIS |
| Type |
CAT |
