| Main Title |
Technical support document on risk assessment of chemical mixtures. |
| CORP Author |
Syracuse Research Corp., NY. ;Cincinnati Univ., OH. Dept. of Environmental Health.;Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, |
| Year Published |
1988 |
| Report Number |
EPA/600/8-90/064; EPA-68-C8-0004; PB91103556 |
| Stock Number |
PB91-103556 |
| OCLC Number |
24416410 |
| Subjects |
Health risk assessment ;
Mixtures
|
| Additional Subjects |
Hazardous materials ;
Chemical compounds ;
Toxicology ;
Mixtures ;
Quantitative analysis ;
Measurement ;
Risk assessment ;
Environmental exposure ;
Health hazards ;
Chemical mixtures ;
Pharmacokinetics ;
Synergism
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJED |
EPA-600/8-90/064 |
|
OCSPP Chemical Library/Washington,DC |
02/20/2009 |
| EKCD |
EPA/600/8-90/064 |
|
CEMM/GEMMD Library/Gulf Breeze,FL |
09/04/2018 |
| ELBD ARCHIVE |
EPA 600-8-90-064 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| ELBD |
EPA 600-8-90-064 |
|
AWBERC Library/Cincinnati,OH |
06/22/2006 |
| NTIS |
PB91-103556 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
1 volume (various pagings) : illustrations ; 28 cm |
| Abstract |
The document was recommended by the U.S. EPA's Science Advisory Board as a means of providing the broad technical background for the principles and procedures described in the 'Guidelines for Health Risk Assessment of Chemical Mixtures'. Unique sections include an overview of available toxicity data on complex mixtures and binary exposures, an estimate of the maximum synergistic effect observed for environmental chemicals, an evaluation of quantitative methods (statistics and models) that have been used in characterizing interaction data base, and recommendations for Guidelines revisions and future research relevant to risk assessment. The two most significant conclusions in the document are (1) that the available literature is extremely poor for use in quantifying the extent of synergism expected from environmental exposures, and (2) that validation of in vitro and short-term in vivo studies seems to be the most promising approach for assessment of complex mixtures. |
| Notes |
"EPA/600/8-90/064." "November 1988." |
| Place Published |
Cincinnati, OH |
| Supplementary Notes |
Prepared in cooperation with Cincinnati Univ., OH. Dept. of Environmental Health. Sponsored by Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office. |
| Access Notes |
Also available via the World Wide Web. |
| Corporate Au Added Ent |
United States. Environmental Protection Agency. Office of Research and Development. |
| Alternate Title |
Risk assessment of chemical mixtures |
| PUB Date Free Form |
1988 |
| Ti Tra Differently |
Risk assessment of chemical mixtures. |
| NTIS Prices |
PC A09/MF A01 |
| BIB Level |
m |
| Medium |
unmediated |
| Content |
text |
| Carrier |
volume |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20180828052613 |
| Language |
eng |
| Origin |
OCLC |
| Type |
MERGE |
| OCLC Rec Leader |
01364cam 2200385Ia 45010 |
