Main Title |
Morphological Effects of Prolonged Exposure to Ozone and Sulfuric Acid Aerosol on the Rat Lung. |
Author |
Moore, P. F. ;
Schwartz, L. W. ;
|
CORP Author |
California Univ., Davis.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1981 |
Report Number |
EPA-68-02-2496; EPA-600/J-81-519; |
Stock Number |
PB82-154857 |
Additional Subjects |
Toxicology ;
Respiratory system ;
Ozone ;
Sulfuric acid ;
Lung ;
Rats ;
Laboratory animals ;
Exposure ;
Aerosols ;
Morphology ;
Pathology ;
Reprints ;
Acids ;
Toxic substances ;
Synergism
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB82-154857 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
18p |
Abstract |
The purpose of this study was to determine the pulmonary effects of a combination of ozone (0.5 ppm) and sulfuric acid aerosol (1 mg/cu. m.) and to assess the possibility of interactive effects. Groups of Sprague-Dawley rats were continously exposed to the pollutants, either individually or combined, for 3, 50, 9O, or 180 days. After 180 days of exposure, additional groups breathed clean air for a further 62 days. Morphological evaluation included light microscopy, autoradiography, scanning electron microscopy (SEM), and transmission electron microscopy. Quantification of pulmonary centriacinar inflammatory cell response was performed by SEM. The results clearly demonstrated that exposure to 0.5 ppm ozone for 180 days resulted in a persistent inflammatory response in the pulmonary centriacinar region together with a structural modification of the terminal bronchiole - proximal alveolar duct junction. Sulfuric acid aerosol did not induce pulmonary morphological changes, nor did it potentiate lesions produced by simultaneous ozone exposure. After termination of the 62-day postexposure period, ozone and ozone plus sulfuric acid postexposure rats demonstrated a marked diminution in the intensity of the pulmonary centriacinar inflammatory response and a partial restoration of normal centriacinar structure. |
Supplementary Notes |
Pub. in Experimental and Molecular Pathology 35, p108-123 1981. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Morphological Effects of Prolonged Exposure to Ozone and Sulfuric Acid Aerosol on the Rat Lung. |
PUB Date Free Form |
5 Jan 81 |
Category Codes |
6T; 6F; 57Y; 68A |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323810578 |
Origin |
NTIS |
Type |
CAT |