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Main Title Carcinogenic potential of rotenone : Phase I : Dietary administration to hamsters /
Author Leber, A. P. ; Persing, R. L.
Other Authors
Author Title of a Work
Persing, R. L.
CORP Author Battelle Columbus Labs., OH.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory ; National Technical Information Service [Distributor],
Year Published 1979
Report Number EPA-600-1-79-004a; EPA-68-02-1715; PB290962
Stock Number PB 290 962
OCLC Number 09365675
Subjects Carcinogenicity testing ; Rotenone
Additional Subjects Toxicology ; Rotenone ; Insecticides ; Pesticides ; Ingestion(Biology) ; Hamsters ; Ketones ; Laboratory animals ; Experimental data ; Bioassay ; Reproduction(Biology) ; Embryos ; Mortality ; Lethal dosage ; Concentration(Composition) ; Sterility ; Males ; Females ; Toxicity ; Diets ; Carcinogens ; Histology ; Pathology ; Toxic substances ; Carcinogenesis ; Birth weight ; Fetuses
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-1-79-004a Headquarters Library/Washington,DC 05/21/2014
EKBD  EPA-600/1-79-004a Research Triangle Park Library/RTP, NC 09/07/2001
ELBD ARCHIVE EPA 600-1-79-004a Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
NTIS  PB-290 962 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation vii, 32 p. : ill. ; 28 cm.
Abstract Studies were performed to evaluate the potential carcinogenicity rotenone in the Syrian Golden hamster. Several ancillary range-finding studies were carried out including 14-day feeding trials and a reproduction experiment. The latter experiment indicated that rotenone at a level of 500 ppm in the maternal diet was embryo-toxic (depressed birth weight and fetal deaths) and resulted in cannabalism of the young by the maternal animals. A level of 1000 ppm led to sterility in one or both sexes. The 18-month carcinogenesis study indicated that 1000 ppm rotenone in the diet was toxic to hamsters (depressed body weights compared to controls) but no gross or histopathological evidence was obtained which indicated that the test compound induced the formation of any tumors. Three adrenal cortical carcinomas in 65 hamsters observed in the 1000 ppm group could not be ascribed to rotenone treatment.
Notes "EPA-600/1-79-004a." "January 1979." "PB-290 962.
Place Published Research Triangle Park, NC Springfield, Va.
Supplementary Notes See also Phase 2, PB-290 963.
Corporate Au Added Ent Health Effects Research Laboratory (Research Triangle Park, N.C.)
PUB Date Free Form 1979
Series Title Traced Research reporting series Environmental health effects research
NTIS Prices PC A03/MF A01
BIB Level m
Medium microform
Cataloging Source OCLC/T
OCLC Time Stamp 20111219134019
Language eng
Origin OCLC
OCLC Rec Leader 01134cam 2200301Ii 45020