| Main Title |
Toxicological Review of Phosgene (CAS No. 75-44-5) in Support of Summary Information on the Integrated Risk Information System (IRIS). |
| CORP Author |
Environmental Protection Agency, Washington, DC. |
| Publisher |
Dec 2005 |
| Year Published |
2005 |
| Report Number |
EPA/635/R-06/001; |
| Stock Number |
PB2006-110282 |
| Additional Subjects |
Toxicity ;
Toxicokinetics ;
Hazard identification ;
Dose-response assessments ;
Humans ;
Epidemiology ;
Laboratory animals ;
Noncancer effects ;
Cancer ;
Susceptible populations ;
Life stages ;
Chlorine organic compounds ;
Toxic substances ;
Phosgene ;
Carbon dichloride oxide ;
Oral reference dose ;
Inhalation reference concentration ;
CAS No 75-44-5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB2006-110282 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
106p |
| Abstract |
This document presents background information and justification for the Integrated Risk Information System (IRIS) Summary of the hazard and dose-response assessment of phosgene. IRIS Summaries may include an oral reference dose (RfD), an inhalation reference concentration (RfC), and a carcinogenicity assessment. The RfD and RfC provide quantitative information for use in risk assessments for health effects known or assumed to be produced through a nonlinear (possibly threshold) mode of action. The RfD (expressed in units of mg/kg-day) is defined as an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime. The inhalation RfC (expressed in units of mg/m3) is analogous to the oral RfD, but provides a continuous inhalation exposure estimate. The inhalation RfC considers toxic effects for both the respiratory system (portal-of-entry) and for effects peripheral to the respiratory system (extrarespiratory or systemic effects). This document does not attempt to develop concentration values protective of acute toxicity. For reference purposes, Appendix A presents a summary of the phosgene Acute Exposure Guideline Levels (AEGLs) that was prepared by the National Academy of Sciences. |
| Availability Notes |
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| Category Codes |
57Y; 68G; 68A |
| NTIS Prices |
PC A07 |
| Primary Description |
100/00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019201050 |
| Origin |
NTIS |
| Type |
CAT |
