| Main Title |
Some Effects of Chronic Tritium Exposure during Selected Ages in the Rat. |
| Author |
Laskey, John W. ;
Bursian., Steven J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, N.C. |
| Year Published |
1976 |
| Report Number |
EPA/600/J-76/061; |
| Stock Number |
PB-268 119 |
| Additional Subjects |
Tritium ;
Radiation effects ;
Radiobiology ;
Dose rate ;
Age ;
Rats ;
Laboratory animals ;
Experimental data ;
Exposure ;
Radioactive isotopes ;
Irradiation ;
Radiation dosage ;
Pregnancy ;
Tables(Data) ;
Pathology ;
Reproductive system ;
Endocrine glands ;
Neurochemistry ;
Reprints
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-268 119 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
To assess the implication of age at the time of exposure to chronic irradiation, rats were exposed to constant tritium (HTO) activities of 10 microcuries/ml of body water for 42 days beginning either on the first day of pregnancy or at birth, or at 42 days or 74 days of age. This activity level provided a calculated whole-body dose rate of 3 rad/day. The indicators of radiobiologic damage employed were reproductive, endocrine, and neurochemical parameters and were assessed at 49, 120, or 300 days of age. A significant reduction in the testes weight and sperm content in rats exposed either from the first day of pregnancy or birth was evident upon examination at 49 days of age. Females exposed from the first day of pregnancy had a significant reduction in their F2 litter size and an increase in the number of resorbed embryos. Analysis for norepinephrine (NE) and dopamine (DA) concentration in the brain and follicle-stimulating hormone (FSH) concentration in the pituitary was performed at 49 and 300 days. |
| Availability Notes |
Pub. in Radiation Research, v67 p314-323 1976. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Some Effects of Chronic Tritium Exposure during Selected Ages in the Rat. |
| PUB Date Free Form |
1976 |
| Category Codes |
6R; 57V; 68F |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323718802 |
| Origin |
NTIS |
| Type |
CAT |
