| Main Title |
Critical Prenatal Periods for Chlorambucil-Induced Functional Alterations of the Rat Kidney. |
| Author |
Kavlock, R. J. ;
Rehnberg, B. F. ;
Rogers, E. H. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/033; |
| Stock Number |
PB87-198388 |
| Additional Subjects |
Kidney ;
Pregnancy ;
Toxicity ;
Rats ;
Congenital abnormalities ;
Reprints ;
Chlorambucil ;
Prenatal exposure delayed effects ;
Neonatal diseases and abnormalities ;
Abnormalities(Drug induced) ;
Enviromental pollutants
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB87-198388 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
16p |
| Abstract |
Previous studies have demonstrated that exposure of rats to chlorambucil during the period of metanephric differentiation results in morphological and functional alterations of the kidneys after birth. The present study describes the effects of chlorambucil treatment at various gestational ages on neonatal renal function. The results demonstrate that the critical period for the induction of specific renal defects and hypoplasia lies on day 11 of gestation, but functional alterations of the kidneys were observed after exposure on day 15 of gestation. |
| Supplementary Notes |
Pub. in Toxicology 43, p51-64 1987. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Critical Prenatal Periods for Chlorambucil-Induced Functional Alterations of the Rat Kidney. |
| PUB Date Free Form |
1987 |
| Category Codes |
57Y; 68G |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
723226531 |
| Origin |
NTIS |
| Type |
CAT |
