| Main Title |
Metabolism of Octamethylcyclotetrasiloxane in the Monkey with Attachments and Cover Letter Dated 05/21/1988. |
| CORP Author |
Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1988 |
| Report Number |
86-880000257 |
| Stock Number |
OTS0514147 |
| Additional Subjects |
Toxicology ;
Health effects ;
Octamethylcyclotetrasiloxane (556-67-2) ;
Pharmaco Kinetics ;
Mammals ;
Monkeys ;
Oral ;
Diet ;
Toxic substances ;
Laboratory animals ;
CAS No 556-67-2
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0514147 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
23p |
| Abstract |
The absorption, distribution, metabolism and elimination of octamethylcyclotetrasiloxane were investigated in 2 monkeys administeredsingle oral doses at a level of 50 mg/kg. The C14-labeled test article was distributed throughout the body and it was absorbed mainly from the gastrointestinal tract. Residual 14C tissue levels 240 hours after oral dosing in microgram/gm equiv. were the following; 3.6 in lymph node, 8.4in mesentery, 13.1 in fat and 5.3 in liver. The major portion of radioactivity excreted was found in the urine with total recoveries of C14 at 63% and 52% while fecal recoveries were 11% and 16% of C14. Threemetabolites were observed; dimethylsilanediol, tetramethyl-1,3-disiloxane diol and hexamethyl-1,5-trisiloxane diol. Themetabolism closely paralled that of 2,6-cis and 2,6-trans-diphenylhexame thylcyclotetrasiloxane. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1988 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801920 |
| Origin |
NTIS |
| Type |
CAT |
