||Metabolism of 2-chloro'u-ring-14c/toluene by Rats Dosed Intravenously.
||Occidental Chemical Corp., Grand Island, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Pharmaco Kinetics ;
Toxic substances ;
Laboratory animals ;
CAS No 95-49-8
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||The metabolism of 2-chlorotoluene was examined in 4 female rats (strain not reported) injected intravenously with a single 0.7 mg/kg dose of (U-ring-14C)2-chlorotoluene. Rats eliminated 69-81% and 14-18% of the applied dose in the urine and as expired volatiles, respectively, within 4 days after dosing. Nearly all of the volatile 14C in expired air was 2-chlorotoluene. The primary urinary metabolites were mercapturic acid, glucuronide, and 2- chlorohippurate, representing 22-24, 13-20, and 7-11% of urinary 14C, respectively.
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||57Y; 57U; 68G; 99; 44G
||PC A03/MF A03