||Evaluation of Octamethylcyclotetrasiloxane as a Potential Inhibitor of Human Cytochrome P450 Enzymes: Amendment to Report No. 1998-I0000-44753, with Cover Letter dated 02/25/1999.
||Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Pharmaco kinetics ;
In vitro ;
CAS No 541-02-6 ;
CAS No 541-05-9 ;
CAS No 556-67-2
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||This study was designed to evaluate the ability of D4 to inhibit the major P450 enzymes in human liver microsomes (namely CYPiA2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4/5 and CYP4A9/11), with the aim of ascertaining the potential of D4 to inhibit the metabolism of drugs and other foreign chemicals. In addition to human liver microsomes, D4 was evaluated for its ability to inhibit CYP1A1/2 and CYP2B1/2 in liver microsomes from rats treated with 3-methylcholanthrene and phenobarbital, respectively.
||The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
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|PUB Date Free Form
||1 Mar 1999
||57Y; 57U; 68G; 99; 44G
||PC A04/MF A04