| Main Title |
Studies on the Percutaneous Absorption of Parathion and Paraoxon. I. Hydrolysis and Metabolism Within the Skin. |
| Author |
Fredriksson, Torsten ;
Farrior, Jr., William L. ;
Witter., Robert F. ;
|
| CORP Author |
Communicable Disease Center, Atlanta, Ga. |
| Year Published |
1961 |
| Stock Number |
PB-280 014 |
| Additional Subjects |
Pesticides ;
Insecticides ;
Toxicology ;
Metabolism ;
Absorption(Biology) ;
Skin(Anatomy) ;
Laboratory animals ;
Cats ;
Rats ;
Rabbits ;
Hydrolysis ;
Reprints ;
Toxic substances ;
Parathion ;
Phosphoric acid/(diethyl-ester)-(nitrophenyl-ester)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-280 014 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
The ability of the skin of man, cat, rabbit, and rat to hydrolyze or otherwise metabolize paraoxon (E 600, or diethyl 4-nitrophenyl phosphate) or parathion (E 605, or diethyl 4-nitrophenyl thiononophospate) was investigated using the Warburg technique and paper chromatography. Parathion was not hydrolyzed or transformed into paraoxon by the skin of any of the species tested. Paraoxon, on the other hand, was hydrolyzed by skin from man, cat, and rabbit. This reaction, which was enzyme in nature, occurred at the fastest rate in the rabbit. In this tissue, about 20 percent of the paraoxon was hydrolyzed in 1 hour by 1 gram of skin at 25C, while only about one percent was converted by skin from man or cat. The relation of these findings to the percutaneous absorption of these compounds was discussed. |
| Supplementary Notes |
Pub. in Acta Dermato Venereologica, v41 p335-343 n.d. |
| Availability Notes |
Included in the report, Journal Articles on Toxicology. Group 11, PB-280 001. |
| Title Annotations |
Reprint: Studies on the Percutaneous Absorption of Parathion and Paraoxon. I. Hydrolysis and Metabolism Within the Skin, |
| PUB Date Free Form |
31 May 61 |
| Category Codes |
6T; 57Y; 68G; 68E |
| NTIS Prices |
(Order as PB-280 001, MF A01) |
| Primary Description |
500/01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323739460 |
| Origin |
NTIS |
| Type |
CAT |
