Main Title |
Biochemical Studies of Six Nitrogen-Containing Heterocycles in Rat Tissues. |
Author |
Kitchin, K. T. ;
Brown, J. L. ;
Lijinsky, W. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;National Cancer Inst., Frederick, MD. Frederick Cancer Research Facility. |
Publisher |
c1989 |
Year Published |
1989 |
Report Number |
EPA/600/J-89/398; |
Stock Number |
PB90-245960 |
Additional Subjects |
Biochemistry ;
Nitrogen heterocyclic compounds ;
Liver ;
Carcinogens ;
Toxicology ;
Leukocytes ;
Lethal dosage ;
Glutathione ;
Esophagus ;
Rats ;
Reprints ;
Ornithine decarboxylase ;
DNA damage ;
Alanine aminotransferase ;
Cytochrome P-450
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-245960 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
Female rats were orally dosed with 1/5 the LD50 of either 1-nitrosopiperidine (a carcinogen), cyclohexylamine, piperidine, 4-carboxy-1-nitrosopiperidine, 4-cyclohexyl-1-nitrosopiperidine or 2 6-dimethyl-1-nitrosopiperidine at 21 and 4 hours before sacrifice. All five noncarcinogenic compounds had no effects on any experimental parameters examined (hepatic DNA damage, ornithine decarboxylase (ODC) activity, serum alanine aminotransferase (SGPT) activity, cytochrome P-450 and glutathione content). After administration of 40 mg/kg of 1-nitrosopiperidine, significant hepatic DNA damage and a 3- to 7-fold increase in the activity of hepatic ODC were observed. 1-Nitrosopiperidine (120 mg/kg, 3/5 LD50) caused DNA damage in rat liver and esophagus but not in leukocytes. The higher dose of 1-nitrosopiperidine also decreased hepatic cytochrome P-450 content by 37% and increased hepatic ornithine decarboxylase activity by 9-fold. As ODC is often induced by tumor-promoters, 1-nitrosopiperidine may have both promoting and initiating properties. (Copyright (c) 1989 Maxwell Pergamon Macmillan plc.) |
Supplementary Notes |
Pub. in Biochemical Pharmacology, v38 n16 p2733-2738 15 Aug 89. Prepared in cooperation with National Cancer Inst., Frederick, MD. Frederick Cancer Research Facility. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Biochemical Studies of Six Nitrogen-Containing Heterocycles in Rat Tissues. |
Category Codes |
57B; 57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
024228505 |
Origin |
NTIS |
Type |
CAT |