Main Title |
Biochemical Effects of Two Promoters of Hepatocarcinogenesis in Rats. |
Author |
Kitchin, K. T. ;
Brown, J. L. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Experimental Biology Div. |
Year Published |
1987 |
Report Number |
EPA/600/J-87/254; |
Stock Number |
PB88-182365 |
Additional Subjects |
Liver neoplasms ;
Phenobarbital ;
Carcinogens ;
Rats ;
Pharmacology ;
Deoxyribonucleic acids ;
Toxicology ;
Alpha amino carboxylic acids ;
Valeric acid ;
Cytochromes ;
Biochemistry ;
Reprints ;
Butylated hydroxytoluene ;
Ornithine decarboxylase
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-182365 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
The effects of administration of two promoters of hepatocarcinogenesis on five hepatic biochemical parameters were examined in adult female rats. Two treatments of phenobarbital (100 mg/kg) 21 and 4 hours before sacrifice caused large increases in hepatic ODC activity and cytochrome P-450 content. Extending the number of phenobarbital treatments to 5 increased the size of hepatic enzyme induction and caused a minor decrease in hepatic glutathione and a small increase in serum alanine aminotransferase. Two administrations of butylated hydroxytoluene (BHT) (700 mg/kg) caused hepatic DNA damage and induction of both ODC activity and cytochrome P-450 content. Of the two compounds only BHT showed a potential for carcinogenic initiation. The biochemical parameters studied here, may form a useful biochemical system to examine a compound's potential to cause carcinogenic initiation, carcinogenic promotion and cellular toxicity. |
Supplementary Notes |
Pub. in Food and Chemical Toxicology, v25 n8 p603-607 1987. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Biochemical Effects of Two Promoters of Hepatocarcinogenesis in Rats. |
PUB Date Free Form |
1987 |
Category Codes |
57B; 57Q; 57F |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
814619695 |
Origin |
NTIS |
Type |
CAT |