Main Title |
Biochemical Effects of Three Carcinogenic Chlorinated Methances in Rat Liver. |
Author |
Kitchin, K. T. ;
Brown, J. L. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1989 |
Year Published |
1989 |
Report Number |
EPA/600/J-89/397; |
Stock Number |
PB90-245978 |
Additional Subjects |
Toxicology ;
Biochemistry ;
Liver ;
Carbon tetrachloride ;
Chloroform ;
Chloromethanes ;
Glutathione ;
Liver neoplasms ;
Lethal dosage ;
Reprints ;
Carcinogenicity tests ;
Cell survival ;
DNA damage ;
Cytochrome P-450 ;
Ornithine decarboxylase ;
Alanine aminotransferase ;
Mutagenicity tests
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-245978 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Three chlorinated methanes, carbon tetrachloride, chloroform and methylene chloride known to cause liver tumors in rodents, were given by oral gavage to adult female rats both 21 and 4 hours before sacrifice. Then hepatic DNA damage, ornithine decarboxylase, cytochrome P-450, glutathione content and serum alanine aminotransferase activity assays were performed. Carbon tetrachloride increased rat hepatic ornithine decarboxylase activity and decreased cytochrome P-450 content at doses both below and above cytotoxicity (as measured by increased serum alanine aminotransferase activity). At 54 and 160 mg/kg, chloroform increased hepatic ornithine decarboxylase activity with minimal or no elevation in serum alanine aminotransferase activity. After oral administration of 480 mg/kg of chloroform, hepatic ornithine decarboxylase activity, serum alanine aminotransferase activity and hepatic DNA damage were increased while hepatic cytochrome P-450 content was decreased. The results with methylene chloride varied between replicates done on three different days. (Copyright (c) 1989 Alan R. Liss, Inc.) |
Supplementary Notes |
Pub. in Teratogenesis, Carcinogenesis, and Mutagenesis, v9 p61-69, Jan 89. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Biochemical Effects of Three Carcinogenic Chlorinated Methances in Rat Liver. |
Category Codes |
57Y; 57B; 57F |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
024228514 |
Origin |
NTIS |
Type |
CAT |