Main Title |
Chloroform Mediated Refractory State Against Ornithine Decarboxylase Induction by Serial Chloroform Treatment. |
Author |
Savage, R. E. ;
Guion, C. ;
DeAngelo, A. B. ;
Pereira, M. A. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;National Inst. for Occupational Safety and Health, Cincinnati, OH. Experimental Toxicology Branch. ;Environmental Health Research and Testing, Inc., Cincinnati, OH. |
Publisher |
c1988 |
Year Published |
1988 |
Report Number |
EPA/600/J-88/382; |
Stock Number |
PB90-103177 |
Additional Subjects |
Toxicology ;
Chloroform ;
Rats ;
Liver ;
Male ;
Female ;
Reprints ;
Enzyme induction ;
Ornithine decarboxylase ;
Neural conduction ;
Dose-response relationships
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-103177 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
6p |
Abstract |
The chloroform mediated refractory state against ornithine decarboxylase induction in male and female rat liver was further studied. One aspect of the investigation was to determine the duration of the induced refractory period while the other component focused on the extent to which the inhibitory effect was dependent upon the concentration of the first dose. When the dosing interval between the first and second dose was varied from 1 to 31 days, the magnitude of the resistance to further stimulation by chloroform only decreased gradually. In studies where the concentration of the first dose was varied while the dosing interval was fixed, it was concluded that the extent of the inhibitory effect was dependent upon the concentration of the first dose. (Copyright 1988 PID Publications Ltd.) |
Supplementary Notes |
Pub. in Research Communications in Chemical Pathology and Pharmacology, v62 n3 p507-510 Dec 88. Prepared in cooperation with National Inst. for Occupational Safety and Health, Cincinnati, OH. Experimental Toxicology Branch, and Environmental Health Research and Testing, Inc., Cincinnati, OH. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Chloroform Mediated Refractory State Against Ornithine Decarboxylase Induction by Serial Chloroform Treatment. |
Category Codes |
57Y; 57I; 68G |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
932616803 |
Origin |
NTIS |
Type |
CAT |