| Main Title |
Percutaneous Absorption of D4 (Octamethylcyclotetrasiloxane). |
| CORP Author |
Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1994 |
| Report Number |
86940001691 |
| Stock Number |
OTS0557972 |
| Additional Subjects |
Toxicology ;
Health effects ;
Octamethylcyclotetrasiloxane (556-67-2) ;
Pharmaco Kinetics ;
Mammals ;
Humans ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 556-67-2
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0557972 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
104p |
| Abstract |
This study evaluated the percutaneous absorption of dimethylcyclosiloxane fluid. Four tissue samples from each of 3 human cadavers was used for these in vitro studies. Five ul doses containing 1.5 uCi radiolabelled dimethylcyclosiloxane fluid were applied to each 1 square centimeter tissue sample. Skin integrity was also evaluated by histopathological examination. Histopathological examination indicated no lesions on the tissue sections. After 24 hours, the total percutaneous absorption (skin compartment and amount absorbed through the skin) was 0.29 percent, 0.47 percent, and 4.4 percent of the applied amount. Greater than 80 percent of the total compound recovered was found in the air traps confirming the relative volatility of this compound. Under conditions of this experiment, the compound was found to volatilize prior to significant absorption. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1994 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A07/MF A07 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803790 |
| Origin |
NTIS |
| Type |
CAT |
