Main Title |
Nickel Absorption and Kinetics in Human Volunteers. |
Author |
Sunderman, F. W. ;
Hopfer, S. M. ;
Sweeney, K. R. ;
Marcus, A. H. ;
Most, B. M. ;
|
CORP Author |
Connecticut Univ. Health Center, Farmington. School of Medicine. ;NSI Technology Services Corp., Research Triangle Park, NC.;Environmental Protection Agency, Research Triangle Park, NC. |
Publisher |
c1989 |
Year Published |
1989 |
Report Number |
EPA-R813456; EPA/600/J-89/270; |
Stock Number |
PB90-198094 |
Additional Subjects |
Nickel ;
Toxicology ;
Humans ;
Kidney ;
Feces ;
Urine ;
Blood serum ;
Graphs(Charts) ;
Reprints ;
Pharmacokinetics ;
Environmental exposure pathways ;
Atomic absorption spectrophotometry
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-198094 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
Mathematical modeling was performed of the kinetics of nickel absorption, distribution and elimination in healthy human volunteers, who ingested NiSO4 in drinking water or added food. Nickel was analyzed by electrothermal atomic absorption spectrophotometry in serum, urine, and feces collected during 2 days before and 4 days after a specified NiSO4 dose (12 ug Ni/kg, N=4; 18 ug Ni/kg, N=4; or 50 ug Ni/kg, N=1). The study confirms that dietary constituents profoundly reduce the bioavailability of Ni2+ for alimentary absorption; approximately one-quarter of nickel ingested in drinking water after an over-night fast is absorbed from the human intestine and excreted in urine, compared to only one percent of nickel ingested in food. The compartmental model and kinetic parameters provided by the study will reduce the uncertainty of toxicological risk assessments of human exposures to nickel in drinking water and food. (Copyright (c) 1989 Society of Experimental Biology and Medicine.) |
Supplementary Notes |
Pub. in Proceedings of the Society for Experimental Biology and Medicine, v191 p5-11 Apr 89. Prepared in cooperation with NSI Technology Services Corp., Research Triangle Park, NC. Sponsored by Environmental Protection Agency, Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Nickel Absorption and Kinetics in Human Volunteers. |
Category Codes |
57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
200/04 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
013033004 |
Origin |
NTIS |
Type |
CAT |