||Exposure of Humans to a Volatile Organic Mixture. 3. Inflammatory Response.
Koren, H. S. ;
Graham, D. E. ;
Devlin, R. B. ;
||Health Effects Research Lab., Research Triangle Park, NC. Human Studies Div.
Indoor air pollution ;
Air pollution effects(Humans) ;
Signs and symptoms ;
Volatile organic compounds
||Some EPA libraries have a fiche copy filed under the call number shown.
||A set of symptoms has been described during the past two decades that has been called the sick building syndrome. These symptoms include eye, nose, and throat irritation; headache; mental fatigue; and respiratory distress. It is likely that the volatile organic compounds (VOCs) present in synthetic materials used in homes and office buildings contribute to these symptoms. However, there have been very few studies in which humans have been exposed to known amounts of VOCs under carefully controlled conditions. In the study, 14 subjects were exposed to a mixture of VOCs (25 mg/sq meter total hydrocarbon) that is representative of what is found in new homes and office buildings. Because irritations of the nose and throat are symptoms often associated with the upper respiratory tract and may result from an inflammatory response in the upper airways, the authors used nasal lavage to monitor neutrophil (PMN) influx into the nasal passages following exposure to VOCs. There were statistically significant increases in PMNs, both immediately after a 4-h exposure to VOCs and 18 h later.
||Pub. in Archives of Environmental Health 47, n1 p39-44 Jan 92. See also PB92-164888.
|NTIS Title Notes
||Reprint: Exposure of Humans to a Volatile Organic Mixture. 3. Inflammatory Response.
||68A; 68G; 57Y; 57J
||PC A02/MF A01