Main Title |
Colony Formation Enhancement of Rat Tracheal and Nasal Epithelial Cells by Polyacetate, Indole Alkaloid, and Phorbol Ester Tumor Promoters. |
Author |
Mass, M. J. ;
Lasley, J. A. ;
Marr, C. M. ;
Arnold, J. T. ;
Steele, V. E. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. |
Year Published |
1987 |
Report Number |
EPA/600/J-87/009; |
Stock Number |
PB87-184677 |
Additional Subjects |
Carcinogens ;
Epithelium ;
Trachea ;
Nose(Anatomy) ;
Rats ;
Laboratory animals ;
Neoplasms ;
Reprints ;
Tumor promoters ;
Colony forming units ;
Polyacetate ;
Indole alkaloid ;
Phorbol ester
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB87-184677 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
5p |
Abstract |
The phorbol ester 12-0-tetradecanoylphorbol-13-acetate (TPA), teleocidin, and two polyacetate tumor promoters (aplysiatoxin and debromoaplysiatoxin) have been tested for their effect on colony forming efficiency (CFE) of rat tracheal and nasal turbinate epithelial cells. In rat tracheal epithelial (RTE) cells, all four compounds stimulated colony formation by up to eight-fold using picomolar concentrations of aplysiatoxin and teleocidin, whereas TPA and debromoaplysiatoxin were effective in the nanomolar range. In addition, teleocidin and the other promoters increased the number of cells in colonies by 3-5 fold resulting in larger colonies, most notably above concentrations that maximally stimulated CFE, In contrast, rat nasal epithelial cells were only marginally stimulated by these tumor promoters to form colonies. The results indicate that there is regional specificity in responses to tumor promoters and RTE cells can act as very sensitive biological indicators of the presence of these three classes of tumor promoters with diverse structure. (Copyright (c) Carcinogenesis vol. 8 no. 1 p. 179-181, 1987.) |
Supplementary Notes |
Pub. in Carcinogenesis, v8 n1 p179-181 1987. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Colony Formation Enhancement of Rat Tracheal and Nasal Epithelial Cells by Polyacetate, Indole Alkaloid, and Phorbol Ester Tumor Promoters. |
PUB Date Free Form |
c1987 |
Category Codes |
57Z; 57O |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
718323436 |
Origin |
NTIS |
Type |
CAT |