||Cytogenetic Studies of Mice Exposed to Styrene by Inhalation.
Kligerman, A. D. ;
Allen, J. W. ;
Bryant, M. F. ;
Campbell, J. A. ;
Collins, B. W. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Chromosome aberrations ;
Sister chromatid exchange ;
Micronucleus tests ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The data for the in vivo genotoxicity of styrene (STY) are equivocal. To evaluate the clastogenicity and sister-chromatid exchange (SCE)-inducing potential of STY in vivo under carefully controlled conditions, B6C3F1 female mice were exposed by inhalation for 6 h/day for 14 consecutive days to either 0, 125, 250 or 500 ppm STY. One day after the final exposure, peripheral blood, spleen, and lungs were removed and cells were cultured for the analysis of micronucleus (MN) induction using the cytochalasin B-block method, chromosome breakage, and SCE induction. Peripheral blood smears were also made for scoring MN in erythrocytes. There was a significant concentration-related elevation of SCE frequency in lymphocytes from the spleen and the peripheral blood as well as in cells from the lung. However, no statistically significant concentration-related increases were found in the frequency of chromosome aberrations in the cultured splenocytes or lung cells, and no significant increases in MN frequencies were observed in binucleated splenocytes or normochromatic erythrocytes in peripheral blood smears. (Copyright (c) 1992 Elsevier Science Publishers B.V.)
||Pub. in Mutation Research 280, n1 p35-43 Jul 92. Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC., and National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Cytogenetic Studies of Mice Exposed to Styrene by Inhalation.
||PC A03/MF A01