||Drinking Water Criteria Document for Di(2-Ethylhexyl) Adipate.
||Dynamac Corp., Rockville, MD.;Environmental Protection Agency, Washington, DC. Office of Drinking Water.
Potable water ;
Water quality ;
Lethal dosage ;
Laboratory animals ;
Water pollution effects(Humans) ;
Water pollution effects(Animals) ;
Health hazards ;
Carcinogenicity tests ;
Path of pollutants ;
Mutagenicity tests ;
Drug antagonism ;
Drug synergism ;
||Some EPA libraries have a fiche copy filed under the call number shown.
||Di(2-ethylhexyl)adipate (DEHA) is a light-colored, oily liquid. It has low solubility in water (0.78 mg/L) and low vapor pressure (0.01 mmHg at 20 deg C). Di(2-ethylhexyl)adipate and other esters of adipic acid (AA) are widely used as plasticizers in a variety of common products including synthetic rubber, food packaging materials, and cosmetics. The acute oral toxicity of DEHA is low. The LD50 estimates in rats and mice range from 9 to 45 g/kg. No data were found in the available literature on the toxic effects of DEHA in humans. The mechanism of DEHA toxicity is not known. Di(2-ethylhexyl)adipate belongs to a diverse group of chemicals that induce the proliferation of hepatic peroxisomes and are associated with hepatic cancer in female mice. It has been suggested that peroxisome proliferation leads to the production of excess amounts of reactive oxygen species that could damage critical macromolecules, such as DNA.
||Sponsored by Environmental Protection Agency, Washington, DC. Office of Drinking Water.
|NTIS Title Notes
||57U; 57Y; 68D
||PC A05/MF A01