| Main Title |
Inhalation Development Toxicity Study in Mice with C-9 Aromatic Hydrocarbons (Draft) with Cover Letter dated 03/15/88. |
| CORP Author |
International Research and Development Corp., Mattawan, MI. ;American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
21 Mar 1988 |
| Year Published |
1988 |
| Report Number |
FYI-AX-0388-0605; |
| Stock Number |
OTS-0000605-0 |
| Additional Subjects |
Aromatic hydrocarbons ;
Toxicity tests ;
Inhalation ;
Environmental exposure ;
Health effects ;
Mice ;
Laboratory animals ;
Maternal toxicity ;
Fetal body weight ;
Developmental defects ;
Birth defects ;
C9 Aromatic hydrocarbons
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000605-0 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
212p |
| Abstract |
Mated Charles River CD(trademark)-1 female mice assigned to one control and three treatment groups of 30 animals each were used to determine the developmental toxicity potential of C(sub 9) Aromatic Hydrocarbons. Actual (measured) concentration levels of 100, 500, and 1,500 ppm were received by the animals through whole body inhalation exposure methods once daily for a 6-hour period. Exposure began on day 6 of gestation and was continued to, and included day 15 of gestation. The control group received filtered air on a comparable regimen. Cesarean sections were performed on all females on gestation day 18 and the fetuses were removed for teratologic evaluation. Exposure to the test article elicited developmental toxicity at the 500 and 1,500 ppm levels. Maternal toxicity was elicited at the 1,500 ppm level. In conclusion, the observable effect of C(sub 9) Aromatic Hydrocarbons with respect to toxicity was considered to be 100 ppm when administered by inhalation methods to Charles River CD-(trademark)-1 mice. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
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| Category Codes |
57Y; 57B; 57U; 68G |
| NTIS Prices |
PC A11/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019102860 |
| Origin |
NTIS |
| Type |
CAT |
