| Main Title |
Inhalation Developmental Toxicology Studies: Teratology Study of N-Hexane in Mice and Rats with Cover Letter dated 08/17/88. |
| CORP Author |
Battelle Pacific Northwest Labs., Richland, WA.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
18 Aug 1989 |
| Year Published |
1989 |
| Report Number |
FYI-OTS-0888-0633; |
| Stock Number |
OTS-0000633 |
| Additional Subjects |
Toxicity ;
Hexane ;
Inhalation ;
Rats ;
Mice ;
Vapors ;
Pregnancy ;
Environmental exposure ;
Gestation ;
Fetus ;
Teratology ;
N-Hexane
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000633 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
405p |
| Abstract |
Timed-pregnant (=33 females per group) and virgin (10 females per group) Swiss (CD-1) mice were exposed to 0 (filtered air), 200, 1000, and 5000 ppm n-hexane (99.2% purity) vapor in inhalation chambers, 20 h/day, for a period of 12 consecutive days. Plug-positive females were exposed on 6-17 days of gestation (dg). Maternal body weight at sacrifice (18 dg) and total cumulative weight gain for dams in the 5000-ppm exposure group were significantly reduced with respect to controls; however, this was due to an exposure-correlated reduction in gravid uterine weight, not to a decrease in extragestational gain. An exposure-correlated decrease in the gravid uterine weight to extragestational weight gain ratio (significant for the 5000-ppm group) occurred in the absence of an effect on placental weight. Gestational exposure to n-hexane resulted in an increase in the number of resorbed fetuses for all exposure groups relative to the control group; however, the increases were not directly correlated to exposure concentration. Gestational exposure of CD-1 mice to n-hexane vapors appeared to cause a degree of concentration-related developmental toxicity in the absence of overt maternal toxicity, but the test material was not found to be teratogenic. |
| Supplementary Notes |
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| Availability Notes |
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| Category Codes |
57Y |
| NTIS Prices |
PC A19/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019102950 |
| Origin |
NTIS |
| Type |
CAT |
