| Main Title |
High Concentrations of Sodium Chloride Induce a 'Positive' Response at the TK Locus of L5178Y/TK(+)/(-)Mouse Lymphoma Cells (Journal Version). |
| Author |
Moore, M. M. ;
Brock, K. H. ;
|
| CORP Author |
Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. |
| Publisher |
c1988 |
| Year Published |
1988 |
| Report Number |
EPA-68-02-4456; EPA/600/J-88/239; |
| Stock Number |
PB89-145072 |
| Additional Subjects |
Sodium chloride ;
Bioassay ;
Cytology ;
Mice ;
Toxicity ;
Thymidines ;
Reprints ;
Mutagenicity tests ;
Stem cells
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-145072 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
The experiment with sodium chloride demonstrates the importance of carefully evaluating weak mutagenic responses observed with high concentrations of test compounds. The positive mutagenicity is likely not due to a direct interaction with DNA but from some indirect mechanism resulting from the extremely nonphysiological condition of the test. A 'blind testing scheme' might conclude that sodium chloride should be tested in the rodent bioassay. For short-term tests to be useful, all results must be carefully analyzed and evaluated using all available information including the likelihood that the test conditions may impact the outcome. To do otherwise compromises the utility of the particular test systems. |
| Supplementary Notes |
Pub. in Environmental and Molecular Mutagenesis, v12 p265-268 1988. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: High Concentrations of Sodium Chloride Induce a 'Positive' Response at the TK Locus of L5178Y/TK(+)/(-)Mouse Lymphoma Cells (Journal Version). |
| Category Codes |
57F; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
908928049 |
| Origin |
NTIS |
| Type |
CAT |
