| Main Title |
Further Evidence That Dichloromethane Does Not Induce Chromosome Damage. |
| Author |
Westbrook-Collins, B. ;
Allen, J. W. ;
Sharief, Y. ;
Campbell, J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
EPA/600/J-90/140; |
| Stock Number |
PB91-109785 |
| Additional Subjects |
Toxicity ;
Carcinogens ;
Solvents ;
Rats ;
Bone marrow ;
Mice ;
In vivo analysis ;
In vitro analysis ;
Reprints ;
Methylene chloride ;
Chromosome aberrations ;
Mutagenicity tests ;
Cultured cells ;
Sister chromatid exchange
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-109785 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
5p |
| Abstract |
Dichloromethane (DCM) is a widely used industrial solvent which has been determined to be a carcinogen in rats and mice. In vitro and in vivo analyses of chromosome damage induced by this agent have provided conflicting results. In order to further investigate the clastogenic potential of DCM in vivo, we analyzed SCEs and chromosome aberrations (CAs) in mouse bone marrow cells following intraperitoneal exposures. DCM failed to increase the frequencies of either SCEs or CAs. |
| Supplementary Notes |
Pub. in Jnl. of Applied Toxicology, v10 n2 p79-81 Apr 90. Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Further Evidence That Dichloromethane Does Not Induce Chromosome Damage. |
| Category Codes |
57Y; 57F |
| NTIS Prices |
PC A01/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
034834733 |
| Origin |
NTIS |
| Type |
CAT |
