Main Title |
Comparison of the Lung Adenoma Response in Strain A/J Mice after Intraperitoneal and Oral Administration of Carcinogens. |
Author |
Stoner, G. D. ;
Greisiger, E. A. ;
Schut, H. A. J. ;
Pereira, M. A. ;
Loeb, T. R. ;
|
CORP Author |
Medical Coll. of Ohio at Toledo.;Health Effects Research Lab., Cincinnati, OH. |
Year Published |
1984 |
Report Number |
EPA/600/J-84/090; |
Stock Number |
PB84-245521 |
Additional Subjects |
Toxicology ;
Adenoma ;
Bioassay ;
Neoplasms ;
Mice ;
Laboratory animals ;
Responses ;
Reprints ;
Carcinogens
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB84-245521 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
14p |
Abstract |
This study was undertaken to compare the ability of a series of compounds from different chemical classes to induce lung tumors in strain A/J mice after either ip or po administration. 3-Methylcholanthrene, benzo(a)pyrene, urethan, diethylnitrosamine, ethylnitrosourea, and dimethylhydrazine induced a significant(p<0.05; t test)increase in the lung tumor response when given both ip and po. 2,4-Dinitrotoluene, 2,6-dinitrotoluene, and a 2:1 mixture of 2,4-dinitrotoluene and 2,6-dinitrotoluene were inactive by both routes of administration and at all dose levels. The lung tumor response to all doses of 3-methylcholanthrene and benzo(a)pyrene, the highest dose of diethylnitrosamine, and the middle doses of both ethylnitrosourea and dimethylhydrazine varied as a function of the route of administration. |
Availability Notes |
Pub. in Toxicology and Applied Pharmacology, v72 p313-323 1984. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Comparison of the Lung Adenoma Response in Strain A/J Mice after Intraperitoneal and Oral Administration of Carcinogens. |
PUB Date Free Form |
c1984 |
Category Codes |
6T; 6E; 57Y; 57O |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
435626999 |
Origin |
NTIS |
Type |
CAT |