| Main Title |
Tumorigenic Responses to Lindane in Mice: Potentiation by a Dominant Mutation. |
| Author |
Wolff, G. L. ;
Roberts, D. W. ;
Morrissey, R. L. ;
Greenman, D. L. ;
Allen, R. R. ;
|
| CORP Author |
National Center for Toxicological Research, Jefferson, AR. ;Pathology Associates, Inc., Ijamsville, MD. ;United Information Systems, McLean, VA. ;Arkansas Univ. for Medical Sciences, Little Rock.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/317; |
| Stock Number |
PB88-196050 |
| Additional Subjects |
Mutation ;
Proto oncogenes ;
Chlorobenzenes ;
Mice(Obese) ;
Obesity ;
Carcinogens ;
Adenoma ;
Carcinoma ;
Hyperplasia ;
Reprints ;
House mouse ;
Lindane ;
Clara cells
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-196050 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
The agouti locus on chromosome 2 in the house mouse regulates the cyclic pattern of eumelanosome and phaeomelanosome (black and yellow pigment granules, respectively) and in the hair bulb. A dominant mutation at the A(viable yellow) locus results in a mouse with increased susceptibility for formation of strain-specific neoplasms, a mottled yellow coat color, and adult-onset obesity. A study of the specific function of this mutation in facilitating development of neoplasia in response to lindane (gamma-hexachlorocyclohexane) exposure in obese mottled yellow A(variable yellow)/a, lean pseudoagouti A(variable yellow/a, and lean black a/a (YS X VY) F-1 hybrid female mice is described. Incidences of Clara cell hyperplasia and prevalences of hepatocellular adenomas and carcinomas are discussed. |
| Supplementary Notes |
Pub. in Carcinogenesis, v8 n12 p1889-1897 1987. Prepared in cooperation with Pathology Associates, Inc., Ijamsville, MD., United Information Systems, McLean, VA., and Arkansas Univ. for Medical Sciences, Little Rock. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Tumorigenic Responses to Lindane in Mice: Potentiation by a Dominant Mutation. |
| PUB Date Free Form |
c1987 |
| Category Codes |
57F; 57Y; 57; 68E; 68G |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
819620441 |
| Origin |
NTIS |
| Type |
CAT |
