| Main Title |
Support document, health effects test rule : chloromethane / |
| CORP Author |
United States. Environmental Protection Agency. Office of Toxic Substances. Assessment Division. |
| Publisher |
U.S. Environmental Protection Agency, Office of Pesticides and Toxic Substances, |
| Year Published |
1980 |
| Report Number |
EPA 560/11-80-015 |
| Stock Number |
PB80-220304 |
| OCLC Number |
08453101 |
| Subjects |
Methyl chloride ;
Environmental health--United States ;
Methyl Chloride--toxicity
|
| Additional Subjects |
Chloromethanes ;
Toxicology ;
Exposure ;
Chlorohydrocarbons ;
Chlorine organic compounds ;
Physiological effects ;
Assessments ;
Laboratory animals ;
Nervous system ;
Signs and symptoms ;
Testing ;
Exposure ;
Toxic substances ;
Toxic Substances Control Act ;
Public Law 94-469
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD ARCHIVE |
EPA 560-11-80-015 |
|
Headquarters Library/Washington,DC |
04/30/2012 |
| EJED |
EPA-560/11-80-015 |
|
OCSPP Chemical Library/Washington,DC |
07/02/1999 |
| ELBD RPS |
EPA 560-11-80-015 |
repository copy |
AWBERC Library/Cincinnati,OH |
01/22/2020 |
| ERAD |
EPA 560/11-80-015 |
|
Region 9 Library/San Francisco,CA |
09/04/2012 |
| NTIS |
PB80-220304 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
83 pages. |
| Abstract |
In 1979 approximately 497 million pounds of chloromethane were produced in the United States solely for domestic consumption. It is used almost exclusively as an intermediate, primarily in the manufacture of silicone and tetramethyllead. Chloromethane exposure has been reported to result in a wide range of systemic toxicity following both acute and chronic exposure. Although effects on the liver, kidney, heart, and hematopoietic system have been demonstrated in both humans and animals, the most sensitive organ seems to be the central nervous system (CNS). Chloromethane has been reported to possess mutagenic activity in bacterial systems that detect gene mutations and to cause chromosomal aberration. Evidence of its mutagenic activity, its in vitro and in vivo alkylating capabilities, and its structural relationship to known or suspected oncogens suggest that chloromethane may possess oncogenic potential. EPA is also concerned with the danger of both structural malformation and behavioral alterations that may be posed by chloromethane. |
| Notes |
Cover title: Assessment of testing needs : chloromethane : support document for proposed health effects test rule, Toxic Substances Control Act, Section 4. "EPA-560/11-80-015." "June 1980." Includes bibliographical references (pages 67-83). |
| Place Published |
Washington, D.C. |
| Access Notes |
Also issued online. |
| Title Ser Add Ent |
TSCA chemical assessment series. |
| Alternate Title |
Chloromethane\ Assessment of testing needs, chloromethane\ Health effects test rule |
| PUB Date Free Form |
1980 |
| Series Title Traced |
TSCA chemical assessment series |
| Series Title Untraced |
TSCA chemical assessment series |
| Ti Tra Differently |
Chloromethane Assessment of testing needs, chloromethane Health effects test rule |
| NTIS Prices |
PC A05/MF A01 |
| BIB Level |
m |
| Document Type |
BC |
| Medium |
unmediated |
| Content |
text |
| Carrier |
volume |
| Cataloging Source |
OCLC/T |
| Merged OCLC records |
7364366; 962867844; 1013352620; 1049738538; 1060546384 |
| OCLC Time Stamp |
20200115090905 |
| Language |
eng |
| SUDOCS Number |
EP 5.15/2:C 45/2 |
| Origin |
OCLC |
| Type |
MERGE |
| OCLC Rec Leader |
02656cam 2200577 a 45010 |
