| Main Title |
Tissue Cell Biocompatibility of dow Corning 200 Fluid, 200 Cs., with Cover Letter dated 4/20/94. |
| CORP Author |
Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1994 |
| Report Number |
86940001426 |
| Stock Number |
OTS0558156 |
| Additional Subjects |
Toxicology ;
Health effects ;
Siloxanes and Silicones ;
Di-me (53148-62-9) ;
Acute Toxicity ;
Mammals ;
Humans ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 63148-62-9
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558156 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
A tissue culture cytotoxicity study was conducted to evaluate the biocompatibility of polydimethylsiloxane (PDMS) fluid with human cells. Dimethylsiloxane, hydroxy-functional silica filled gum served as the negative control; while latex catheter served as the positive control. Each test material was used to saturate a sterile 1.3 cm filter pad, which was placed in direct contact with a confluent monolayer of human embryonic foreskin cells and incubated for 24 hours. After incubation, the cultures were examined microscopically at 10x magnification and compared to positive and negative controls to evaluate cytotoxicity. The results of these examinations were reported as no cytopathic effect or as a cytopathic effect, rated as 1, 2, or 3. A rating of 1 denoted a slight reaction; 2 represented a distinct reaction in areas around the sample with no cell death evident; 3 represented a severe reaction with cells dead and areas of the cell sheet lifted. No cytopathic effect was reported for the polydimethylsiloxane fluid. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1994 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A02/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803880 |
| Origin |
NTIS |
| Type |
CAT |
