| Main Title |
Support: Letter from Dow to USEPA Summarizing Preliminary Results of a 90-Day Oral (Gavage) and 1-Generation Reproductive Toxicity Study of Trifluoropropylmethy lcyclotrisiloxane, dated 09/04/2001. |
| CORP Author |
Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2001 |
| Report Number |
8EHQ-0901-14868 |
| Stock Number |
OTS0560003-1 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Cyclotrisiloxane ;
2 ;
4 ;
6-trimethyl-2 ;
4 ;
6-tris(3 ;
3 ;
3-trifluor) ;
Subchronic toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
CAS No 2374-14-3
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0560003-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
Preliminary results from an ongoing 13-week subchronic and one generation reproductive study with TFPMCT show test article-related changes in liver, heart, and skeletal muscle. In the liver, periportal hepatocyte enlargement with micro to macrovacuolation of the cytoplasm was observed at a Lowest Observed Effect level (LOEL) of 0.8 mg/kg/day. In the heart, test article-related or test article-exacerbated cardio- myopathy was observed at a LOEL of 4.0 mg/kg/day (and possibly at 0.8 mg/kg/day in males). Degeneration in the skeletal muscle was seen at a LOEL of 20 mg/kg/day and was characterized by changes in the shape and size of myocytes, loss of cross striations, and increased cellularity (mononuclear inflammatory cells and/or regenerative myocyte nuclei). |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
10 Sep 2001 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A02/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010502040 |
| Origin |
NTIS |
| Type |
CAT |
