| Main Title |
Support: Evaluation of Reproductive Organ Development in CF-1 Mice Following Prenatal Exposure to Bisphenol A, with Cover Letter dated 10/14/1998. |
| CORP Author |
Society of the Plastics Industry, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1998 |
| Report Number |
8EHQ-1098-13581 |
| Stock Number |
OTS0558455-3 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
4 ;
4'-isopropylidene-2-diphenol ;
Reproduction ;
Fertility effects ;
Teratogenicity ;
Mammals ;
Oral ;
Gavage ;
CAS No 80-05-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558455-3 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
832p |
| Abstract |
The objective of this study was to evaluate the effects of the test article (Bisphenol A, BPA) on male sexual development, as measured by sex organ weights, daily sperm production (DSP), epididymal sperm count and testis histopathology in the offspring of female mice exposed to the test article by deposition in the mouth on Days 11 to 17 of gestation. This study was conducted to investigate and further elucidate potential effects on male reproductive organs of low dose exposure to BPA during prenatal development applying a protocol for treatment as described by Nagel et al., (1997) and vom Saal et al., (1998). The study was not intended to establish either the maximum tolerated doses ofBPA or define the upper bound of a no observed effect level as required in regulatory guidelines. Groups of 28 females were administered 0.2, 2.0, 20 or 200 pg/kg/day of BPA in tocopherol- stripped corn oil, once daily on Days 11 to 17 of gestation. Two negative control groups of 28 mice/group were dosed with tocopherol-stripped corn oil only. An additional.group of 28 females administered 0.2 gg/kg/day of diethylstilbestrol (DES) in the corn oil vehicle for the same time period served as a positive control. The dose level of DES was selected based on an expected maximum effect on the developing prostate as communicated by vom Saal (1996) and published by vom Saal et al., (1997a). The 2.0 and 20 pg/kg/day doses of BPA were selected to repeat the exposure scenario used by vom Saal (1998) and Nagel et al., (1997). The 0.2 and 200 pg/kg/day BPA dose levels were selected to provide additional information at a dose below and a dose above those chosen by vom Saal (1998) and Nagel et al., (1997). Following the exposure period, the dams were allowed to deliver and raise their pups. On Day 22 of lactation, the litters were weaned, and a maximum of 4 males/litter were retained until 90 days of age. Following weaning, the adult females, all female pups, and extra male pups were euthanized. At 90 days of age, the male offspring (maximum of 4/litter) were euthanized and necropsied for evaluation of selected reproductive parameters. Following statistical comparison of the two negative control groups, these groups were combined into 1 negative control group for statistical evaluation of treatment related effects. |
| Supplementary Notes |
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| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
22 Oct 1998 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A99/MF A99 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500070 |
| Origin |
NTIS |
| Type |
CAT |
