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Main Title Effects of Low Subchronic Doses of Methoxychlor on the Rat Hypothalamic-Pituitary Reproductive Axis.
Author Goldman, J. M. ; Cooper, R. L. ; Rehnberg, G. L. ; Hein, J. F. ; McElroy, W. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/316;
Stock Number PB87-176889
Additional Subjects Reproduction(Biology) ; Pesticides ; Hypothalamus ; Gonadotropic hormones ; Reproductive system ; Male genital diseases ; Fertility ; Rats ; Reprints ; Methoxychlor ; Infertility
Library Call Number Additional Info Location Last
NTIS  PB87-176889 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Abstract The purpose of this study was to explore the influence of methoxychlor (MXC) upon the pituitary and hypothalamic components of the male reproductive system at dose levels that were without detectable testicular effects. At 21 days, male Long-Evans rats were gavaged daily with 25 or 50 mg/kg MXC in corn oil. Controls received vehicle only. After 8 weeks of dosing, no significant changes were seen in serum LH, FSH, or prolactin, nor in the pituitary concentrations of LH or FSH. Pituitary prolactin was elevated for both doses, and pituitary fragments perifused in vitro released more prolactin than controls. The concentration of gonadotropin-releasing hormone (GnRH) was higher in the mediobasal hypothalamus, but only for the 50 mg/kg group. At this dose, there was a corresponding increase in the KCL-stimulated release of GnRH. The data suggest that previously reported reproductive effects of MXC may be mediated, at least in part, through an elevation in prolactin concentration and release, which in turn is able to influence hypothalamic levels in GnRH.
Supplementary Notes Pub. in Toxicology and Applied Pharmacology 86, p474-483 1986.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effects of Low Subchronic Doses of Methoxychlor on the Rat Hypothalamic-Pituitary Reproductive Axis.
PUB Date Free Form 1986
Category Codes 68E; 68G; 57S; 57H; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 716921374
Origin NTIS
Type CAT