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Main Title Induction of Cytochrome P-450-IA1 in Juvenile Fish by Creosote-Contaminated Sediment.
Author Schoor, W. P. ; Williams, D. E. ; Takahashi., N. ;
CORP Author Environmental Research Lab., Gulf Breeze, FL. ;Oregon State Univ., Corvallis. Dept. of Food Science and Technology.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/342;
Stock Number PB92-129790
Additional Subjects Water pollution effects(Animals) ; Cytochrome P-450 ; Sediments ; Poecilia ; Creosote ; Liver ; Pathology ; Mixed function oxidases ; Enzyme induction ; Immunohistochemistry ; Liquid chromatography ; Carcinogens ; Reprints ;
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NTIS  PB92-129790 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Abstract Intact sediment cores, including their surface layers, were used in simulated field exposure tests of juvenile guppies (Poecilia reticulata) to creosote-contaminated sediments. Mixed-function oxygenase activity was induced in the fish after 43 days of exposure to environmentally realistic, sublethal concentrations of creosote-related compounds. An average 50-fold induction in the cytochrome P-450-IA1 was found in the liver in the absence of any histopathological lesions. The possibility that a threshold level for proliferative liver changes was not reached is discussed in the light of the observed biochemical activation.
Supplementary Notes Pub. in Archives of Environmental Contamination and Toxicology, v20 p497-504 1991. See also PB88-251699. Prepared in cooperation with Oregon State Univ., Corvallis. Dept. of Food Science and Technology.
NTIS Title Notes Journal article.
Title Annotations Reprint: Induction of Cytochrome P-450-IA1 in Juvenile Fish by Creosote-Contaminated Sediment.
Category Codes 68D; 57Y; 57F
NTIS Prices PC A02/MF A01
Primary Description 600/04
Document Type NT
Cataloging Source NTIS/MT
Control Number 205224032
Origin NTIS
Type CAT