| Main Title |
Induction of Cytochrome P-450-IA1 in Juvenile Fish by Creosote-Contaminated Sediment. |
| Author |
Schoor, W. P. ;
Williams, D. E. ;
Takahashi., N. ;
|
| CORP Author |
Environmental Research Lab., Gulf Breeze, FL. ;Oregon State Univ., Corvallis. Dept. of Food Science and Technology. |
| Publisher |
c1991 |
| Year Published |
1991 |
| Report Number |
EPA/600/J-91/342; |
| Stock Number |
PB92-129790 |
| Additional Subjects |
Water pollution effects(Animals) ;
Cytochrome P-450 ;
Sediments ;
Poecilia ;
Creosote ;
Liver ;
Pathology ;
Mixed function oxidases ;
Enzyme induction ;
Immunohistochemistry ;
Liquid chromatography ;
Carcinogens ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-129790 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Intact sediment cores, including their surface layers, were used in simulated field exposure tests of juvenile guppies (Poecilia reticulata) to creosote-contaminated sediments. Mixed-function oxygenase activity was induced in the fish after 43 days of exposure to environmentally realistic, sublethal concentrations of creosote-related compounds. An average 50-fold induction in the cytochrome P-450-IA1 was found in the liver in the absence of any histopathological lesions. The possibility that a threshold level for proliferative liver changes was not reached is discussed in the light of the observed biochemical activation. |
| Supplementary Notes |
Pub. in Archives of Environmental Contamination and Toxicology, v20 p497-504 1991. See also PB88-251699. Prepared in cooperation with Oregon State Univ., Corvallis. Dept. of Food Science and Technology. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Induction of Cytochrome P-450-IA1 in Juvenile Fish by Creosote-Contaminated Sediment. |
| Category Codes |
68D; 57Y; 57F |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
205224032 |
| Origin |
NTIS |
| Type |
CAT |
