| Main Title |
5,7-Dihydroxytryptamine Injections Increase Glial Fibrillary Acidic Protein in the Hypothalamus of Adult Rats. |
| Author |
Frankfurt, M. ;
O'Callaghan, J. ;
Beaudet, A. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Rockefeller Univ., New York. Lab. of Neuroendocrinology. ;Montreal Neurological Inst. (Quebec). Neuroanatomy Lab. |
| Publisher |
c1991 |
| Year Published |
1991 |
| Report Number |
EPA/600/J-91/020; |
| Stock Number |
PB92-143924 |
| Additional Subjects |
Glial fibrillary acidic protein ;
Hypothalamus ;
5-7-dihydroxytryptamine ;
Rats ;
Astrocytes ;
Serotonin ;
Radioimmunoassay ;
Immunohistochemistry ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-143924 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
5p |
| Abstract |
The distribution and level of glial fibrillary acidic protein (GFAP) were determined in the adult rat hypothalamus following axotomy of serotonin (5-HT) neurons. Seven days after unilateral intrahypothalamic injection of the 5-HT neurotoxic, 5,7-dihydroxytryptamine, there was a marked increase in the number of GFAP-labelled astrocytes in the ipsilateral hypothalamus of 5,7-DHT-treated as compared to sham-treated rats. Measurement of GFAP levels demonstrated a significant increase on the ipsilateral side of 5,7-DHT-treated rats as compared to sham-treated rats. |
| Supplementary Notes |
Pub. in Brain Research, v549 n1 p138-140 May 91. See also PB91-117077. Prepared in cooperation with Rockefeller Univ., New York. Lab. of Neuroendocrinology, and Montreal Neurological Inst. (Quebec). Neuroanatomy Lab. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: 5,7-Dihydroxytryptamine Injections Increase Glial Fibrillary Acidic Protein in the Hypothalamus of Adult Rats. |
| Category Codes |
57Y; 57F |
| NTIS Prices |
PC A01/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
208728750 |
| Origin |
NTIS |
| Type |
CAT |
